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OPC3373, a lesser known metabolite, was identified above the cutoff level in 93% of samples.

When a clinician orders urine drug testing for a patient prescribed chronic opioid therapy (COT), it is essential that the results are interpreted correctly because they often have significant clinical implications.

Testing methods may be limited by the availability of compounds used as reference standards.

Reference standards are known materials used by laboratories to compare patient samples, and often are accompanied by certificates detailing the prepared concentration and purity.

Clinicians who prescribe opioids must make every effort to ensure that the prescriptions given to a patient are used by that individual and not misused.

Thus, when a clinician receives urine drug test results with a negative result, it is imperative that the potential reasons are clearly understood so that the appropriate clinical decision can be made.

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Recently, this occurrence was demonstrated when patients were tested for the antipsychotic medication aripiprazole (Abilify).

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